Table of Contents
ISRN Nanotechnology
Volume 2012, Article ID 143613, 12 pages
Research Article

An Approach to Tentative Reference Levels Setting for Nanoparticles in the Workroom Air Based on Comparing Their Toxicity with That of Their Micrometric Counterparts: A Case Study of Iron Oxide Fe3O4

Department of Toxicology and Biological Prophylaxis, Medical Research Center for Prophylaxis Health Protection in Industrial Workers, 30 Popov Street, Ekaterinburg 620014, Russia

Received 24 April 2012; Accepted 7 June 2012

Academic Editors: Q. Chen and J. Ding

Copyright © 2012 Boris A. Katsnelson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We overview the state of the art in the field of safe exposure levels setting for nanomaterials together with the previously published results of our experimental investigations characterizing comparative toxicity of the iron oxide F e 3 O 4 (magnetite) in the form of microparticles and nanoparticles of different size and comparative activity of the defensive alveolar phagocytosis response to their pulmonary deposition. An approach to the substantiation of acceptable workplace exposure limits of metallic nanoparticles is discussed and, specifically, the tentative reference level for magnetite nanoparticles is recommended.