162802.fig.001a
(a)
162802.fig.001b
(b)
162802.fig.001c
(c)
Figure 1: (a) State 3 respiration is the slope of measured O2 consumption in the presence of glutamate-malate and ADP. *, significantly different than low-glucose and high-glucose + C-peptide ( 𝑃 < 0 . 0 2 ). (b) State 4 respiration is the slope of measured O2 consumption after ADP depletion. (c) RCR is the ratio of state 3 to state 4 respiration. *, significantly less than low-glucose and high-glucose + C-peptide (* 𝑃 < 0 . 0 0 0 1 ). 𝑛 = 8 experiments. Data represent mean ± SEM.