TY - JOUR A2 - Komada, F. A2 - Froldi, G. A2 - Gervasini, G. A2 - Edwards, G. A2 - Biala, G. A2 - Cerecetto, H. AU - Qinna, Nidal A. AU - Kamona, Basma S. AU - Alhussainy, Tawfiq M. AU - Taha, Hashem AU - Badwan, Adnan A. AU - Matalka, Khalid Z. PY - 2012 DA - 2012/07/02 TI - Effects of Prickly Pear Dried Leaves, Artichoke Leaves, Turmeric and Garlic Extracts, and Their Combinations on Preventing Dyslipidemia in Rats SP - 167979 VL - 2012 AB - The successful use of herbal combinations in managing diseases or conditions over a single herb has lead us to evaluate the anti-dyslipidemic properties of the combination of the artichoke leaves extract, turmeric extract, prickly pear dried leaves (PPL) and garlic extract versus each one alone in two different hyperlipidemic animal models. A two-week treatment of each of the natural extracts, combination 1 (artichoke, turmeric and PPL) or combination 2 (artichoke, turmeric, PPL and garlic) prior to a single intraperitoneal injection of Pluronic F-127 resulted in decreasing significantly serum LDL levels by garlic and PPL extracts and serum LDL/HDL ratios by turmeric, PPL, combination 1 and 2. In a 10-day high fat diet model, only the combination 1 and 2 lowered serum cholesterol, LDL by 8–12%, decreased significantly triglycerides, LDL/HDL ratio; and increased significantly HDL (P<0.0001). However, a long term treatment of each natural product for 7 weeks resulted in decreasing significantly serum LDL levels and LDL/HDL ratio (P<0.050.0001). Furthermore, only artichoke and PPL inhibited significantly HMG-CoA reductase activity (P<0.05). In conclusion, short term, as well as long term, treatment using the combination of artichoke, turmeric, PPL and garlic extract prevents dyslipidemia; partially through inhibiting HMG-CoA reductase. SN - null UR - https://doi.org/10.5402/2012/167979 DO - 10.5402/2012/167979 JF - ISRN Pharmacology PB - International Scholarly Research Network KW - ER -