Table of Contents
ISRN Pharmacology
Volume 2012 (2012), Article ID 167979, 7 pages
http://dx.doi.org/10.5402/2012/167979
Research Article

Effects of Prickly Pear Dried Leaves, Artichoke Leaves, Turmeric and Garlic Extracts, and Their Combinations on Preventing Dyslipidemia in Rats

1Department of Pharmacology and Biomedical Sciences, Faculty of Pharmacy and Medical Sciences, Petra University, Amman 11196, Jordan
2Delass Natural Products, Naour 11710, Jordan
3Jordanian Pharmaceutical Manufacturing Co. PLC. (JPM), Naour 11710, Jordan

Received 4 April 2012; Accepted 3 May 2012

Academic Editors: G. Biala, H. Cerecetto, G. Edwards, G. Froldi, G. Gervasini, and F. Komada

Copyright © 2012 Nidal A. Qinna et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The successful use of herbal combinations in managing diseases or conditions over a single herb has lead us to evaluate the anti-dyslipidemic properties of the combination of the artichoke leaves extract, turmeric extract, prickly pear dried leaves (PPL) and garlic extract versus each one alone in two different hyperlipidemic animal models. A two-week treatment of each of the natural extracts, combination 1 (artichoke, turmeric and PPL) or combination 2 (artichoke, turmeric, PPL and garlic) prior to a single intraperitoneal injection of Pluronic F-127 resulted in decreasing significantly serum LDL levels by garlic and PPL extracts and serum LDL/HDL ratios by turmeric, PPL, combination 1 and 2. In a 10-day high fat diet model, only the combination 1 and 2 lowered serum cholesterol, LDL by 8–12%, decreased significantly triglycerides, LDL/HDL ratio; and increased significantly HDL ( 𝑃 < 0 . 0 0 0 1 ). However, a long term treatment of each natural product for 7 weeks resulted in decreasing significantly serum LDL levels and LDL/HDL ratio ( 𝑃 < 0 . 0 5 0 . 0 0 0 1 ). Furthermore, only artichoke and PPL inhibited significantly HMG-CoA reductase activity ( 𝑃 < 0 . 0 5 ). In conclusion, short term, as well as long term, treatment using the combination of artichoke, turmeric, PPL and garlic extract prevents dyslipidemia; partially through inhibiting HMG-CoA reductase.