Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice

Figure 3

Effects of repeated administrations of saline or 1 mg/kg of NIC (a), 10 mg/kg of BUP (b), or 4 mg/kg of MP (c) to the same ICR mice on ambulatory activity. The administration was repeated 5 times with intervals of 3-4 days. Symbols represent mean values of ambulatory activity for 60 min periods after the administrations, and vertical lines indicate SEM. Saline: 𝑁=60, NIC: 𝑁=20, BUP: 𝑁=60, and MP: 𝑁=100. *𝑃<0.05 compared with saline control at the same time point. ^#𝑃<0.05 compared with the first administration of the drug.

(a)

(b)

(c)