Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice

<table>Effects of combined administration of 2 mg/kg of NIC with 1 mg/kg of MECA on ambulatory activity. Filled columns indicate mean values of total ambulatory activity for 60 min after the administrations, and vertical lines indicate SEM. Saline + saline: <svg height="10.9125" id="M42" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 48.4375 10.9125" width="48.4375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.9125)">
<g transform="translate(72,-63.27)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑁</tspan>
<tspan style="font-size: 12.50px; " x="14.103384" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="26.143772" y="0">8</tspan>
<tspan style="font-size: 12.50px; " x="32.395271" y="0">0</tspan>
</text>
</g>
</g>
</svg>, NIC + saline: <svg height="10.9125" id="M43" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 48.4375 10.9125" width="48.4375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.9125)">
<g transform="translate(72,-63.27)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑁</tspan>
<tspan style="font-size: 12.50px; " x="14.103384" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="26.143772" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="32.395271" y="0">0</tspan>
</text>
</g>
</g>
</svg>, and NIC + MECA: <svg height="10.9125" id="M44" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 48.4375 10.9125" width="48.4375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.9125)">
<g transform="translate(72,-63.27)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑁</tspan>
<tspan style="font-size: 12.50px; " x="14.103384" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="26.143772" y="0">4</tspan>
<tspan style="font-size: 12.50px; " x="32.395271" y="0">0</tspan>
</text>
</g>
</g>
</svg>. *<svg height="11.25" id="M45" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 56.150002 11.25" width="56.150002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.25)">
<g transform="translate(72,-63)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">&lt;</tspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="29.182001" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="38.559254" y="0">5</tspan>
</text>
</g>
</g>
</svg> compared with NIC + saline.</table>

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fig4

Figure 4

Figure 4: Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice 