Table of Contents
ISRN Obstetrics and Gynecology
Volume 2012, Article ID 172808, 7 pages
Review Article

Early Detection of Maternal Risk for Preeclampsia

1Department of Obstetrics and Gynecology, University Hospital Essen, Hufelandstraße 55, 45147 Essen, Germany
2Institute of Molecular Biology, University Hospital, Hufelandstraße 55, 45147 Essen, Germany
3Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London SE5 9RS, UK

Received 8 April 2012; Accepted 19 June 2012

Academic Editors: K. Chan, A. Malek, A. Martin-Hidalgo, and C. Romero

Copyright © 2012 B. Mikat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Preeclampsia is one of the leading causes of maternal and fetal morbidity and mortality. New molecular insights offer new possibilities of early diagnosis of elevated maternal risk. Maternal risk factors, biophysical parameters like Doppler examination of the uterine arteries and biochemical parameters allow early risk calculation. Preventive and effective therapeutic agents like acetylsalicylacid can be started in the early second trimester. This article reviews the diagnostic possibilities of early risk calculation to detect women having high risk for preeclampsia and the potential benefits for them, the offspring and health care systems. We provide risk calculation for preeclampsia as an important and sensible part of first trimester screening.