Table of Contents
ISRN Pharmaceutics
Volume 2012 (2012), Article ID 195727, 10 pages
Review Article

Drug Solubility: Importance and Enhancement Techniques

Institute of Pharmacy, Nirma University, Sarkhej Gandhinagar Highway, Gujarat, Ahmedabad 382481, India

Received 31 March 2012; Accepted 8 May 2012

Academic Editors: G. Aktay, Y.-Z. Du, and J. Torrado

Copyright © 2012 Ketan T. Savjani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. More than 40% NCEs (new chemical entities) developed in pharmaceutical industry are practically insoluble in water. Solubility is a major challenge for formulation scientist. Any drug to be absorbed must be present in the form of solution at the site of absorption. Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include physical and chemical modifications of drug and other methods like particle size reduction, crystal engineering, salt formation, solid dispersion, use of surfactant, complexation, and so forth. Selection of solubility improving method depends on drug property, site of absorption, and required dosage form characteristics.