CCN1 Induces -Catenin Translocation in Esophageal Squamous Cell Carcinoma through Integrin 11
Figure 3
CCN1 upregulates gene expression of ITGA11 and ITGB5 in esophageal epithelial cells. Cells were cultured in the absence (control) or presence of CCN1 for the times indicated. Total RNA was isolated and reverse-transcribed with Biotin-16-dUTP to generate cDNA probes, which were then hybridized to the cDNA microarrays. (a) Array layout with integrins is marked in bold. Integrins further analyzed in the study are in red. (b) Gene expression profile with marked (circled) integrins of interest. ITGA11 and ITGB5 are upregulated by CCN1.
