Table of Contents
ISRN Pathology
Volume 2012, Article ID 217162, 15 pages
Review Article

Mitochondrial Markers for Cancer: Relevance to Diagnosis, Therapy, and Prognosis and General Understanding of Malignant Disease Mechanisms

Laboratories for Neuropathology & Mitochondrial Disorders, Ghent University Hospital, Building K5 3rd Floor, De Pintelaan 185, 9000 Ghent, Belgium

Received 25 September 2012; Accepted 15 October 2012

Academic Editors: B. Azadeh, T. Kovács, P. J. Twomey, and T. Yazawa

Copyright © 2012 Boel De Paepe. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cancer cells display changes that aid them to escape from cell death, sustain their proliferative powers, and shift their metabolism toward glycolytic energy production. Mitochondria are key organelles in many metabolic and biosynthetic pathways, and the adaptation of mitochondrial function has been recognized as crucial to the changes that occur in cancer cells. This paper zooms in on the pathologic evaluation of mitochondrial markers for diagnosing and staging of human cancer and determining the patients’ prognoses.