Mitochondrial Markers for Cancer: Relevance to Diagnosis, Therapy, and Prognosis and General Understanding of Malignant Disease Mechanisms

Figure 1

Mitochondrial diagnostic and prognostic biomarkers and their dominant intracellular location. Bcl-2 interacting protein-3 like (BNIP3L), fumarate hydratase (FH), gene associated with retinoid-interferon-induced mortality (GRIM), coproporphyrinogen III oxidase (HemN), heat shock protein (HSP), inner mitochondrial membrane (IMM), isocitrate dehydrogenase (IDH), mitochondrial matrix (MM), outer mitochondrial membrane (OMM), oxidative phosphorylation (OXPHOS), pyruvate dehydrogenase (PDH), pyruvate dehydrogenase kinase (PDK), pyruvate kinase type M (PKM), peroxidase (POD), polymerase γ (POLG), translocase of the inner mitochondrial membrane (TIMM), translocase of the outer mitochondrial membrane (TOMM), tumor necrosis factor-associated protein (TRAP), translocator protein (TSPO).