Simultaneous Estimation of Metoprolol Succinate and Olmesartan Medoxomil in Pharmaceutical Formulation by Thin-Layer Chromatographic-Densitometric Method

Table 3

Summary of validation parameters of developed HPTLC method.

Validation parameters	MET	OLM
Linear range (𝜂g per band)	1000–2250	800–1800
LOD^(a) (𝜂g per band)	249.61	210.05
LOQ^(b) (𝜂g per band)	823.72	693.15
Accuracy (%)	99.85–101.07%	99.08–101.29%
Repeatability of measurement of peak area (RSD^(c) %, 𝑛=6)	0.1218	0.0742
Repeatability of sample application (RSD%, 𝑛=6)	0.5823	0.2957
Precision (RSD %)
Intraday (𝑛=3)	0.1547	0.0821
Interday (𝑛=3)	0.1108	0.0442

^(a)Limit of detection.
^(b)Limit of quantification.
^(c)Relative standard deviation.
𝑛 = number of determinations.