Biological Markers and Response to Neoadjuvant Taxane-Based Chemotherapy in Patients with Locally Advanced Breast Cancer

Table 5

Relation of Her 2/neu to p53, hormonal receptor status, grade, tumor size, lymph node status, and patients' age.

Variable	Number	Her2/neu+     (𝑛=20)		Her2/neu−; (𝑛=75)		P value
		Number	%	Number	%
Hormonal receptor (HmR)						<0.0001
HmR+	74	2	2.7	72	97.3
HmR−	21	18	85.7	3	14.3
p53 status						=0.412
Inactive p53	29	8	27.6	21	72.4
Intact P53	66	12	18.2	54	81.8
Grade						<0.0001
G II	65	4	6.2	61	93.8
G III	30	16	53.3	14	47.7
Tumor size						=1
<5 cm	9	2	22.2	7	77.8
≥5 cm	86	18	20.1	68	79.9
Lymph node status						=0.0039
N0	19	0	0	19	100
N1	55	11	20	44	80
N2	21	9	42.9	12	57.1
Age						=0.0108
<50 years	57	17	29.8	40	70.2
≥50 years	38	3	7.9	35	92.1