Neuronal Nicotinic Receptors in Sleep-Related Epilepsy: Studies in Integrative Biology

Table 1

Ionotropic ACh and GABA receptors. Nomenclature and related monogenic epilepsies.

Receptor	Subunit	Gene	Epilepsy
Muscle nAChR	𝛼1	CHRNA1
	𝛽1	CHRNB1
	𝛾	CHRNG
	𝛿	CHRND
	𝜀	CHRNE
Neuronal nAChR	𝛼2	CHRNA2	Sleep-related epilepsy
	𝛼3	CHRNA3
	𝛼4	CHRNA4	ADNFLE
	𝛼5-𝛼10	CHRNA5–CHRNA10
	𝛽2	CHRNB2	ADNFLE
	𝛽3	CHRNB3
	𝛽4	CHRNB4
GABA receptors	𝛼1	GABRA1	JME, CAE
	𝛼2-𝛼6	GABRA2–GABRA6
	𝛽1	GABRB1
	𝛽2	GABRB2
	𝛽3	GABRB3	CAE
	𝛾1	GABRG1
	𝛾2	GABRG2	FS, CAE, DS, GEFS+
	𝛾3	GABRG3
	𝛿	GABRD	FS, GEFS+
	𝜀	GABRE
	𝜃	GABRQ
	𝜌1-𝜌3	GABRR1–GABRR3
	𝜋	GABRP

Legend. ADNFLE: autosomal dominant nocturnal frontal lobe epilepsy; CAE: childhood absence epilepsy; DS: Dravet syndrome; GEFS+: generalized epilepsy with febrile seizures plus; JME: juvenile myoclonic epilepsy. For reference about GABA receptors and epilepsy, see [48].