International Scholarly Research Notices / 2012 / Article / Tab 1 / Research Article
Plasma Drug Level Validates Self-Reported Adherence but Predicts Limited Specificity for Nonadherence to Antiretroviral Therapy Table 1 The association between patientsβ demographic/clinical characteristics and plasma drug therapeutic concentration among patients on a stavudine-containing regimen in Uganda.
Plasma drug concentration Crude association Below normal range1 Within or above normal range2 Odds ratio (95%CI)
π
-valueSelf-report Adherence Below 95% (
π
=
4
0
) 26 (65.0%) 14 (35.0%) [reference] <0.0001 95% and above (
π
=
1
9
4
) 42 (21.7%) 152 (78.4%) 6.72 (3.06, 14.78) Gender Male (
π
=
8
4
) 23 (27.4%) 61 (72.6%) [reference] 0.6728 Female (
π
=
1
5
0
) 45 (30.0%) 105 (70.0%) 0.88 (0.49, 1.59) Age in years Mean (SD) 38.4 (7.0) 38.6 (6.9) 1.00 (0.96, 1.05) 0.833 Employment status Not Employed (
π
=
9
6
) 23 (24.0%) 73 (76.0%) [reference] 0.2079 Employed (
π
=
1
3
3
) 42 (31.6%) 91 (68.4%) 0.68 (0.38, 1.24) Marital Status Not married (
π
=
1
0
6
) 24 (22.6%) 82 (77.4%) [reference] 0.0496 Married (
π
=
1
2
8
) 44 (34.4%) 84 (65.6%) 0.56 (0.31, 1.01) Education No Education (
π
=
1
6
) 5 (31.3%) 11 (68.8%) [reference] 0.8419 Some Education (
π
=
2
1
8
) 63 (28.9%) 155 (71.1%) 1.12 (0.37, 3.36) Alcohol drinking status Never (
π
=
1
4
4
) 42 (29.2%) 102 (70.8%) [reference] 0.7946 Stopped drinking (
π
=
2
6
) 8 (30.8%) 18 (69.2%) 0.93 (0.37, 2.29) Still drinking (
π
=
6
0
) 15 (25.0%) 45 (75.0%) 1.24 (0.62, 2.45) Current CD4 count in cells/mL Mean (SD) 289 (180) 292 (141) 1.00 (1.00, 1.00) 0.916 Body weight in kgs Mean (SD) 61.9 (9.9) 62.9 (10.0) 1.01 (0.98, 1.04) 0.520
1 2
