Table of Contents
ISRN Endocrinology
Volume 2012, Article ID 276742, 8 pages
Research Article

Do Surgical Interventions Influence Psychosexual and Cosmetic Outcomes in Women with Disorders of Sex Development?

1Division of Pediatric Endocrinology, Department of Pediatrics, Erasmus MC-Sophia, P.O. Box 2060, 3000 CB Rotterdam, The Netherlands
2Division of Pediatric Endocrinology, Department of Pediatrics, Ghent University and University Hospital Ghent, De Pintelaan 185, 9000 Ghent, Belgium
3Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
4Department of Urology, Erasmus MC-Sophia, P.O. Box 1738, 3000 CB Rotterdam, The Netherlands

Received 14 November 2011; Accepted 25 December 2011

Academic Editor: R. Rey

Copyright © 2012 Nina Callens et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Clinical practice developed to promote psychosexual well-being in DSD is under scrutiny. Although techniques for genital surgery have much improved lately, long-term studies on psychosexual functioning and cosmetic outcome on which to base treatment and counseling are scarce. We studied 91 women with a DSD. Feminizing surgery was performed in 64% of the women; in 60% of them, resurgery in puberty was needed after a single-stage procedure. Both patients and gynecologists were satisfied with the cosmetic appearance of the genitalia. However, forty percent of these females experienced sexuality-related distress and 66% was at risk for developing a sexual dysfunction, whether they had surgery or not. Recognizing the difficulty of accurate assessment, our data indicate that feminizing surgery does not seem to improve nor hamper psychosexual outcome, especially in patients with severe virilization.