International Scholarly Research Notices / 2012 / Article / Fig 1

Research Article

Neural Circuit in the Dorsal Raphe Nucleus Responsible for Cannabinoid-Mediated Increases in 5-HT Efflux in the Nucleus Accumbens of the Rat Brain

Figure 1

Systemic effect of CB1 receptor agonists on 5-HT efflux in the DRN and NAcc. Data are expressed as percent of average baseline values (% mean ± s.e.m.). Mean baseline level of extracellular 5-HT was 0 . 6 2 ± 0 . 0 2  pg/sample in the DRN ( 𝑛 = 2 4 ) and 0 . 3 1 ± 0 . 0 1  pg/sample in the NAcc ( 𝑛 = 4 4 ). The arrow indicates the time of the injection. (a) Systemic injection of WIN 55,212-2 (2.5 and 5 mg/kg, i.p.) had no effect on extracellular 5-HT in the DRN. (b) Systemic injection of WIN 55,212-2 (2.5 and 5 mg/kg, i.p.) produced dose- and time-dependent effects on extracellular 5-HT in the NAcc. (c) Systemic injection of CP55940 (0.25 and 0.5 mg/kg, i.p.) produced dose- and time-dependent effects on extracellular 5-HT in the NAcc. * 𝑃 < 0 . 0 5 and *** 𝑃 < 0 . 0 0 1 versus vehicle examined by the repeated measures ANOVA followed by the post hoc Scheffe test.
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276902.fig.001b
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