International Scholarly Research Notices / 2012 / Article / Fig 2

Research Article

Neural Circuit in the Dorsal Raphe Nucleus Responsible for Cannabinoid-Mediated Increases in 5-HT Efflux in the Nucleus Accumbens of the Rat Brain

Figure 2

Effects of CB1 and opioid receptor antagonists on WIN 55,212-2-induced increases in 5-HT in the nucleus accumbens. Data are expressed as percent of average baseline values (% mean ± s.e.m.). Mean baseline level of extracellular 5-HT was 0 . 3 9 ± 0 . 0 4  pg/sample in the NAcc ( 𝑛 = 4 5 ). The arrows indicate the time of injection of antagonists 30 min before WIN 55,212-2. The effect of WIN 55,212-2 on 5-HT efflux in the NAcc was blocked by SR 147778 (5 mg/kg i.p.; (a)) and AM251 (5 mg/kg, i.p; (b)), but not by naloxone (10 mg/kg, s.c.; (c)). * 𝑃 < 0 . 0 5 and *** 𝑃 < 0 . 0 0 1 versus vehicle examined by the repeated measures ANOVA followed by post hoc Scheffe test.
276902.fig.002a
(a)
276902.fig.002b
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276902.fig.002c
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