International Scholarly Research Notices / 2012 / Article / Fig 5

Research Article

Neural Circuit in the Dorsal Raphe Nucleus Responsible for Cannabinoid-Mediated Increases in 5-HT Efflux in the Nucleus Accumbens of the Rat Brain

Figure 5

Effect of systemic cannabinoids on GABA efflux in the DRN. The arrow indicates the time of injection of 5 mg/kg WIN 55,212-2, 0.5 mg/kg CP55940, or vehicle at 𝑡 = 0 minutes. Data are expressed as percent of average baseline values (% mean ± s.e.m.). Mean baseline level of extracellular GABA was 0 . 3 2 ± 0 . 0 6  pmol/sample. There was a significant reduction in GABA efflux in the DRN following systemic injection of WIN 55,212-2 or CP55945. * 𝑃 < 0 . 0 5 , ** 𝑃 < 0 . 0 1 , and *** 𝑃 < 0 . 0 0 1 versus vehicle examined by the repeated measures ANOVA followed by post hoc Scheffe test.
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