Neural Circuit in the Dorsal Raphe Nucleus Responsible for Cannabinoid-Mediated Increases in 5-HT Efflux in the Nucleus Accumbens of the Rat Brain

Figure 5

Effect of systemic cannabinoids on GABA efflux in the DRN. The arrow indicates the time of injection of 5 mg/kg WIN 55,212-2, 0.5 mg/kg CP55940, or vehicle at 𝑡=0 minutes. Data are expressed as percent of average baseline values (% mean ± s.e.m.). Mean baseline level of extracellular GABA was 0.32±0.06 pmol/sample. There was a significant reduction in GABA efflux in the DRN following systemic injection of WIN 55,212-2 or CP55945. *𝑃<0.05, **𝑃<0.01, and ***𝑃<0.001 versus vehicle examined by the repeated measures ANOVA followed by post hoc Scheffe test.