Neural Circuit in the Dorsal Raphe Nucleus Responsible for Cannabinoid-Mediated Increases in 5-HT Efflux in the Nucleus Accumbens of the Rat Brain
Effect of systemic cannabinoids on GABA efflux in the DRN. The arrow indicates the time of injection of 5 mg/kg WIN 55,212-2, 0.5 mg/kg CP55940, or vehicle at minutes. Data are expressed as percent of average baseline values (% mean ± s.e.m.). Mean baseline level of extracellular GABA was pmol/sample. There was a significant reduction in GABA efflux in the DRN following systemic injection of WIN 55,212-2 or CP55945. *, **, and *** versus vehicle examined by the repeated measures ANOVA followed by post hoc Scheffe test.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.