Fluorometric Determination of Drugs Containing α-Methylene Sulfoxide Functional Groups Using 𝑁¹- Methylnicotinamide Chloride as a Fluorogenic Agent

Table 6

Intraday and interday precision data of 1–5 in standard solutions using the proposed method.

Drug	Claimed conc.	Intraday			Interday
		Found conc.*	S.D.	C.V.	Found conc.*	S.D.	C.V.
1 μg/mL	1	0.995	0.035	0.354%	0.99	0.007	0.71%
	3	3.01	0.007	0.235%	2.98	0.014	0.473%
	12	11.99	0.007	0.058%	12.02	0.014	0.118%
	15	15.01	0.007	0.047%	15.025	0.018	0.118%
	20	19.98	0.014	0.071%	20.01	0.007	0.035%
	30	30.015	0.011	0.035%	29.99	0.007	0.024%
	40	39.95	0.035	0.088%	39.98	0.014	0.036%
	50	49.715	0.202	0.404%	50.01	0.007	0.014%
2 ng/mL	50	50.1	0.07	0.14%	49.8	0. 14	0.28%
	320	322	1.4	0.44%	320	0.0	0.0%
	600	600.1	0.07	0.012%	602	0.14	0.24%
	1150	1151	0.71	0.615%	1145	3.535	0.308%
	1200	1198	1.41	0.1179%	1203	2.121	0.176%
3 ng/mL	100	101	0.71	0.703%	99	0.71	1.4%
	300	299	0.71	0.24%	298	1.41	0.47%
	1200	1202	1.141	0.118%	1202	1.141	0.118%
	1300	1298	1.41	0.11%	1303	2.121	0.163%
	1500	1499	0.71	0.47%	1504	2.83	0.188%
4 ng/mL	100	101	0.707	0.704%	99	0.707	0.71%
	300	302	1.414	0.469%	303	2.12	0.703%
	400	399	0.707	0.177%	402	1.414	0.353%
	600	598	1.414	0.236%	597	2.12	0.354%
	800	798	1.414	0.176%	799	0.71	0.088%
	1000	1004	2.828	0.282%	1005	3.54	0.353%
	1200	1195	3.53	0.295%	1201	0.71	0.059%
	1500	1497	2.12	0.142%	1504	2.83	0.188%
5 ng/mL	20	20.2	0.14	0.7%	19.7	0.21	1.07%
	200	201	0.71	0.35%	202	1.41	0.71%
	600	605	3.5	0.6%	596	2.83	0.47%
	800	791	6.36	0.8%	806	4.3	0.53%
	1000	990	7.1	0.71%	1012	8.5	0.84%
	1500	1490	7.1	0.47	1518	12.8	0.84%
	2000	1985	10.6	0.53%	2009	6.4	0.32%
	2200	2220	14.14	0.64%	2190	7.1	0.15%

*Average of triplicate analyses for each concentration.