Table of Contents
ISRN Molecular Biology
Volume 2012, Article ID 304021, 8 pages
Research Article

Inner Membrane Protein YhcB Interacts with RodZ Involved in Cell Shape Maintenance in Escherichia coli

Department of Biology, Faculty of Science, Kobe University, Rokko, Kobe, Hyogo 657-8501, Japan

Received 29 June 2012; Accepted 22 July 2012

Academic Editors: H. Lim and A. Maucuer

Copyright © 2012 Gaochi Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Depletion of YhcB, an inner membrane protein of Escherichia coli, inhibited the growth of rodZ deletion mutant showing that the loss of both YhcB and RodZ is synthetically lethal. Furthermore, YhcB was demonstrated to interact with RodZ as well as several other proteins involved in cell shape maintenance and an inner membrane protein YciS of unknown function, using bacterial two-hybrid system. These observations seem to indicate that YhcB is involved in the biogenesis of cell envelope and the maintenance of cell shape together with RodZ.