Predictive and Prognostic Factors in Definition of Risk Groups in Endometrial Carcinoma

Table 6

Multivariate Cox proportional regression analyses of prognostic factors.

Factor	Risk ratio	95% CI	P value
Overall survival rate
Age (>60 years)	2.951	2.467–3.531	<0.00001
FIGO stage (III-IV versus I-II)	2.489	2.169–2.855	<0.00001
Histology*	1.569	1.340–1.836	<0.00001
FIGO grade (3 versus 1-2)	1.814	1.590–2.069	<0.00001
Nuclear grade (3 versus 1-2)	1.558	1.286–1.888	<0.00001
DNA ploidy**	1.456	1.215–1.744	<0.0001
Myometrial infiltration***	1.322	1.164–1.501	<0.0001
P53 expression****	0.955	0.715–1.276	0.755
Cancer-specific survival rate
Age (>60 years)	1.925	1.509–2.456	<0.00001
FIGO stage (III-IV versus I-II)	4.205	3.542–4.993	<0.00001
Histology*	1.717	1.410–2.090	<0.00001
FIGO grade (3 versus 1-2)	2.524	2.099–3.035	<0.00001
Nuclear grade (3 versus 1-2)	1.635	1.279–2.090	<0.0001
DNA ploidy**	1.591	1.267–1.999	<0.0001
Myometrial infiltration***	1.292	1.069–1.561	0.008
P53 expression****	1.089	0.747–1.587	0.657

^*Nonendometrioid versus endometrioid. **Nondiploid versus diploid. ***>50% versus <50%. ****Positive (>30% staining) versus negative (<30% staining).