Table of Contents
ISRN Urology
Volume 2012, Article ID 342796, 8 pages
http://dx.doi.org/10.5402/2012/342796
Clinical Study

Morbidity and Quality of Life in Bladder Cancer Patients following Cystectomy and Urinary Diversion: A Single-Institution Comparison of Ileal Conduit versus Orthotopic Neobladder

1Department of Urology, Charité-University Medicine Berlin, 10117 Berlin, Germany
2Department of Urology, University Hospital Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany
3Department of Urology, University Hospital Magdeburg, 39120 Magdeburg, Germany

Received 4 November 2011; Accepted 29 November 2011

Academic Editor: V. Serretta

Copyright © 2012 Barbara Erber et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To evaluate and compare noncontinent and continent urinary diversion after radical cystectomy in patients with bladder cancer. Methods. A total of 301 patients submitted to radical cystectomy at the Charité-University Hospital Berlin from 1993 to 2007 including 146 with an ileal conduit and 115 with an ileal neobladder. Clinical and pathological data as well as oncological outcome were retrospectively analyzed and compared. Quality of life was analyzed using the EORTC QLQ-C30 and BLM30 questionnaires. Results. 69.1% and 69.6% of all patients who received an ileal conduit and ileal neobladder, respectively, developed early complications. The two groups differed significantly concerning the occurrence of postoperative ileus ( 𝑃 = 0 . 0 2 ) favoring patients who received an ileal conduit but not with regard to any other early-onset complication evaluated. Patients with ileal neobladder had a significantly better global health status and quality of life ( 𝑃 = 0 . 0 2 ), better physical functioning ( 𝑃 = 0 . 0 2 ), but also a higher rate of diarrhoea ( 𝑃 = 0 . 0 0 4 ). Conclusion. Cystectomy with any type of diversion remains a complication-prone surgery. Even if the patient groups are not homogeneous in all respects, there are many arguments in favor of the ileal neobladder as the urinary diversion of choice.