Angiotensin Type 1a Receptor Signaling Is Not Necessary for the Production of Reactive Oxygen Species in Polymorphonuclear Leukocytes

Figure 2

H₂O₂ production in PMNs. (a) Level of H₂O₂ in polymorphonuclear leukocytes (PMLs) from Ang II type 1a receptor knockout mice (AT1KO), C57BL/6 wild type mice (Control; 𝑛=6), and C57BL/6 wild type mice treated with losartan (ARB; 𝑛=6) after addition of S. aureus. **𝑃<0.01; compared to control mice (Control) at baseline. (b) H₂O₂ levels in polymorphonuclear leukocytes (PMLs) from Ang II type 1a receptor knockout mice (AT1KO; 𝑛=4), C57BL/6 wild type mice (Control; 𝑛=6), and C57BL/6 wild type mice treated with losartan (ARB; 𝑛=6) after phorbol myristate acetate (PMA) stimulation. **𝑃<0.01; compared to wild-type mice (Control) at baseline.

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