Review Article

An Emerging Role for Serine Protease Inhibitors in T Lymphocyte Immunity and Beyond

Figure 8

Protection of bystander cells from damage by T lymphocytes. PI9 inhibits the PCD of bystander cells induced by GrB after the delivery of a lethal hit (lightening bolt) by CTL. PI9 controls the secretion of proinflammatory IL-1 by inhibiting caspase 1 in endothelial cells.
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