An Emerging Role for Serine Protease Inhibitors in T Lymphocyte Immunity and Beyond
Figure 8
Protection of bystander cells from damage by T lymphocytes. PI9 inhibits the PCD of bystander cells induced by GrB after the delivery of a lethal hit (lightening bolt) by CTL. PI9 controls the secretion of proinflammatory IL-1 by inhibiting caspase 1 in endothelial cells.