Effect of Chronic L-Dopa or Melatonin Treatments after Dopamine Deafferentation in Rats: Dyskinesia, Motor Performance, and Cytological Analysis
Figure 2
Mean latencies to cross two narrow beams (6 and 12 mm) (±SEM) before and after 6-OHDA lesion and during treatments. Note that from the beginning of LD treatment the rats improve their motor behavior until 21 days and afterwards showed a significant increase in the time to transverse the beam compared to controls. In contrast, the time to cross the beam of melatonin-treated rats until day 21th was similar to those animals with lesion and no treatment; afterwards the time was reduced drastically resembling the values of the control group (∗ versus control group; • LD-treated group versus melatonin-treated group; ANOVA test).
