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ISRN Gastroenterology
Volume 2012 (2012), Article ID 362805, 7 pages
Research Article

Gastric Ulceration in Diabetes Mellitus: Protective Role of Vitamin C

1Department of Physiology, College of Medical Sciences, University of Calabar, Calabar, PMB 1115, Nigeria
2Department of Basic Medical Sciences, The University of West Indies, Mona Campus, Kingston 7, Jamaica

Received 13 March 2012; Accepted 18 April 2012

Academic Editors: A. Nakao and C. Sperti

Copyright © 2012 Daniel U. Owu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The effect of vitamin C administration on gastric acid secretion and ulcer in diabetic rats was studied. Vitamin C (200 mg/kg b.w.) was administered to both streptozotocin-induced diabetic and control groups orally for 28 days. Gastric acid secretion was measured and ulcer was induced using ethanol. Histological changes were observed in the stomach. Basal and stimulated acid secretion in diabetic control rat was significantly ( 𝑃 < 0 . 0 1 ) decreased when compared to vitamin C-treated diabetic group and control. Administration of vitamin C significantly ( 𝑃 < 0 . 0 5 ) increased the histamine-stimulated gastric acid secretion in diabetics than control while reduction in gastric secretion by ranitidine was similar compared with control. Vitamin C treatment significantly ( 𝑃 < 0 . 0 5 ) reduced ulcer index in diabetic group and increased mucus weight when compared with diabetic group which was also confirmed with photomicrographs. The mean body weight of diabetic rats treated with vitamin C was comparable to the control. The blood glucose level was significantly ( 𝑃 < 0 . 0 1 ) reduced in diabetic group given vitamin C ( 8 . 9 Β± 1 . 8  mMol/L) compared to the diabetic control ( 3 2 . 2 Β± 2 . 1  g). It is concluded that vitamin C is beneficial in improving gastric acid secretion and protects against ulceration in streptozotocin-induced diabetes mellitus in rats due to its antioxidant potential.