Response Surface Optimization of Sustained Release Metformin-Hydrochloride Matrix Tablets: Influence of Some Hydrophillic Polymers on the Release
Figure 4
Scanning electron (SEM) photomicrographs of matrix tablets employing HPMC K4M and HPMC K100M (FF3) showing surface morphology after 0 mins ((a), 200×), 2 hrs ((b), 200×), 6 hrs ((c), 200×), 9 hrs ((d), 200×), and 9 hrs ((e), 1000×) of dissolution study. (c, d, e) arrows indicate the formation of pores in the matrices and subsequent eruption and leaching of drug.
