Research Article
Response Surface Optimization of Sustained Release Metformin-Hydrochloride Matrix Tablets: Influence of Some Hydrophillic Polymers on the Release
Table 5
-values and -values obtained according to Korsmeyer-Peppas and Weibull kinetic model.
| | Formulations | “” values | Type of transport | “” values | Type of transport |
| | FF1 | 0.651 | Non-Fickian | 1.145 | Sigmoid indicative of complex release mechanism | | FF2 | 0.889 | Non-Fickian anomalous | 1.415 | Sigmoid indicative of complex release mechanism | | FF3 | 1.085 | Non-Fickian anomalous | 1.587 | Sigmoid indicative of complex release mechanism | | FF4 | 0.951 | Non-Fickian anomalous | 1.435 | Sigmoid indicative of complex release mechanism | | FF5 | 1.1 | Non-Fickian anomalous | 1.612 | Sigmoid indicative of complex release mechanism | | FF6 | 0.921 | Non-Fickian anomalous | 1.355 | Sigmoid indicative of complex release mechanism |
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