Table of Contents
ISRN Inflammation
Volume 2012 (2012), Article ID 382862, 5 pages
Clinical Study

sTREM-1 as a Prognostic Marker of Postoperative Complications in Cardiac Surgery

Research Institute for Complex Issues of Cardiovascular Diseases, The Siberian Branch of The Russian Academy of Medical Sciences, 650002 Kemerovo, Russia

Received 30 October 2012; Accepted 5 December 2012

Academic Editors: E. Alhan and R. Ovstebo

Copyright © 2012 A. S. Golovkin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cell-activating receptor TREM-1 (triggering receptor expressed on myeloid cells 1) regulates congenital immune response and contributes to systemic inflammatory response syndrome (SIRS) development. It is able to multiply cytokine production while stimulated together with the main receptors of the congenital immune system. The purpose of the paper is to study the potential use of soluble TREM-1 (sTREM-1) as a marker of intensive SIRS and a criterion for postoperative complications prediction following on-pump coronary artery bypass surgery (CABG). Results show that early postoperative sTREM-1 concentrations demonstrate their potential prognostic value regarding SIRS-associated complications.