Table of Contents
ISRN Physical Chemistry
Volume 2012 (2012), Article ID 391897, 5 pages
http://dx.doi.org/10.5402/2012/391897
Research Article

Docking Applied to the Study of Inhibitors of c-Met Kinase

Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, 47 and 115, La Plata B1900BJW, Argentina

Received 8 September 2011; Accepted 22 September 2011

Academic Editors: B.-T. Liu and A. Liwo

Copyright © 2012 Luciana Gavernet et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Quinoxaline derivatives were studied as inhibitors of c-Met kinase, a receptor associated with high tumor grade and poor prognosis in a number of human cancers. In this paper we used docking methodologies to predict the binding conformation of a set of quinoxalines and to explain the differences of biological activities previously reported.