Table of Contents
ISRN Organic Chemistry
Volume 2012, Article ID 404235, 8 pages
Research Article

N-tert-Butoxycarbonylation of Structurally Diverse Amines and Sulfamides under Water-Mediated Catalyst-Free Conditions

LCOA, Bioorganic Chemistry Group, Chemistry Department, Sciences Faculty, Badji Mokhtar-Annaba University, P.O. Box. 12, 23000 Annaba, Algeria

Received 24 January 2012; Accepted 22 February 2012

Academic Editors: B. Das, G. Li, and P. Sanchez-Andrada

Copyright © 2012 Zinelaabine Cheraiet et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A simple, efficient, and eco-friendly protocol for the N-Boc protection of the amine moiety in a variety of compounds with di-tert-butyl dicarbonate under water-acetone catalyst-free conditions is described. The corresponding monocarbamate is obtained in excellent yields on short reaction times. No competitive side reactions such as isocyanate urea and O-Boc were observed. This method represents a reasonable alternative to the previous reported protection procedures.