Modulating Anti-MicroRNA-21 Activity and Specificity Using Oligonucleotide Derivatives and Length Optimization
Influence of UNA monomers on AMO activity. Fold increase of luciferase activity measured after treatment with 100 nM AMO, comparing the 22AMO with phosphorothioate backbone and 32% LNA with the 22AMO with LNA/UNA. UNA content improved mismatch discrimination.
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