Modulating Anti-MicroRNA-21 Activity and Specificity Using Oligonucleotide Derivatives and Length Optimization

<table>Influence of UNA monomers on AMO activity. Fold increase of luciferase activity measured after treatment with 100 nM AMO, comparing the 22AMO with phosphorothioate backbone and 32% LNA with the 22AMO with LNA/UNA. UNA content improved mismatch discrimination.</table>

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Figure 5

Figure 5: Modulating Anti-MicroRNA-21 Activity and Specificity Using Oligonucleotide Derivatives and Length Optimization 