Pharmacokinetics and Biodistribution Study of 7A7 Anti-Mouse Epidermal Growth Factor Receptor Monoclonal Antibody and Its Fragment in an Immunocompetent Mouse Model
Figure 3
Biodistribution of 125I-7A7 mAb in C57BL/6 mice. After a single i.v. injection of 2.8 mg per Kg of radiolabeled 7A7 mAb (12.0 MBq/mg), groups of three mice were sacrificed and liver, kidneys, lungs, and spleen were excised, rinsed of residual blood, and weighted. Radioactivity levels were measured at 4, 24, and 48 h using a γ-counter. Graphs represent the percentage of the initial injected dose/g tissue (%D/g).
