Pharmacokinetics and Biodistribution Study of 7A7 Anti-Mouse Epidermal Growth Factor Receptor Monoclonal Antibody and Its F(ab^′)_𝟐 Fragment in an Immunocompetent Mouse Model

Table 1

Pharmacokinetic parameters of ¹²⁵I-7A7 mAb (2.8 mg per Kg/12.0 MBq/mg) after a single i.v. injection in C57BL/6 mice (𝑛=3).

	Pharmacokinetic parameters of ^125I-7A7 mAb in C57BL/6 mice
	𝑡1/2𝛽 (h)	AUC (𝜇g/mL·h)	CL (mL/h)	Vss (mL)
7A7 mAb	23.1±0.4	801.1±8.9	0.06±0.001	1.41±0.03

Data are expressed as the mean ± SD.
𝑡_1/2: elimination half-life; AUC: area under the curve; CL: clearance; Vss: volume of the distribution at a steady state.