Clinical Study

Safety and Efficacy of the ACE-Inhibitor Ramipril in Alport Syndrome: The Double-Blind, Randomized, Placebo-Controlled, Multicenter Phase III EARLY PRO-TECT Alport Trial in Pediatric Patients

Table 1

Alport syndrome levels describing renal damage and loss of function.

StageDefinition

0Microhaematuria without microalbuminuria (usually at birth)
IMicroalbuminuria (30–300 mg albumin/gCrea)
IIProteinuria >300 mg albumin/gCrea
III>25% decline of normal renal function (creatinine clearance)
IVEnd-stage renal failure (ESRF)