Table of Contents
ISRN Pharmaceutics
Volume 2012, Article ID 436763, 9 pages
Review Article

A Review of Hot-Melt Extrusion: Process Technology to Pharmaceutical Products

1School of Science, University of Greenwich, Central Avenue, Chatham Maritime, Chatham, Kent ME4 4TB, UK
2Department of Pharmaceutical Sciences, Medway School of Science, University of Greenwich, Chatham Maritime, Kent ME4 4TB, UK

Received 3 October 2012; Accepted 30 October 2012

Academic Editors: A. Bolognese, Y. Murata, H. Sah, and A. I. Segall

Copyright © 2012 Mohammed Maniruzzaman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Over the last three decades industrial adaptability has allowed hot-melt extrusion (HME) to gain wide acceptance and has already established its place in the broad spectrum of manufacturing operations and pharmaceutical research developments. HME has already been demonstrated as a robust, novel technique to make solid dispersions in order to provide time controlled, modified, extended, and targeted drug delivery resulting in improved bioavailability as well as taste masking of bitter active pharmaceutical ingredients (APIs). This paper reviews the innumerable benefits of HME, based on a holistic perspective of the equipment, processing technologies to the materials, novel formulation design and developments, and its varied applications in oral drug delivery systems.