Capsaicin, a TRPV1 Ligand, Suppresses Bone Resorption by Inhibiting the Prostaglandin E Production of Osteoblasts, and Attenuates the Inflammatory Bone Loss Induced by Lipopolysaccharide

Figure 3

Effects of capsaicin on femoral bone mass in mice injected with LPS. The mice were injected with (+) LPS (10 mg/kg of body weight) or PBS (−) i.p. on days 0 and 4 with or without capsaicin (1 mg/kg of body weight). The femurs were collected on day 8 after the first injection to measure the bone mineral density (BMD). BMD of distal femurs was measured by dual X-ray absorptiometry (model DCS-600R; Aloka). Data are expressed as the mean ± SEM of 6–9 mice. A significant difference between the two groups is indicated, *𝑃<0.001 versus control; ^##𝑃<0.001 versus LPS.