Table of Contents
ISRN Oncology
Volume 2012, Article ID 450267, 12 pages
http://dx.doi.org/10.5402/2012/450267
Research Article

Molecular Profiles of Pre- and Postoperative Breast Cancer Tumours Reveal Differentially Expressed Genes

1Department of Surgery, Akershus University Hospital, 1478 Lørenskog, Norway
2Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway
3Department of Clinical Molecular Biology and Laboratory Sciences (EpiGen), Akershus University Hospital, 1478 Lørenskog, Norway
4The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ 08540, USA
5Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway
6Department of Pathology, Akershus University Hospital, 1478 Lørenskog, Norway
7Institute of Health Promotion, Akershus University Hospital, 1478 Lørenskog, Norway

Received 31 August 2012; Accepted 18 October 2012

Academic Editors: E. A. Rakha and S. Ran

Copyright © 2012 Margit L. H. Riis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1: Hierarchal clustering with all probes present on the array of the pre- and postoperative samples together with corresponding adjacent normal tissue shows overall similar expression profiles for the majority of the pre- and postoperative tumor pairs.

Supplementary Figure 2: Hierarchical clustering of the samples using the differently expressed genes (FDR < 2.5%) separates the majority of the preoperative tumors from the corresponding postoperative tumors.

Supplementary Figure 3: Molecular network showing the interaction between all the 228 differently expressed genes. The gene identifiers and corresponding expression values were uploaded into in the Ingenuity Pathway Analysis. Networks were then algorithmically generated based on their connectivity in Ingenuity's Knowledge Base. Molecules are represented as nodes, and the biological relationship between two nodes is represented as an edge (line). The intensity of the node color indicates the degree of up- (red) or down- (green) regulation. Nodes are displayed using various shapes that represent the functional class of the gene product.

Supplementary Table 1: Significantly differently expressed genes between pre- and postoperative samples. All probes with FDR < 2.5% ranked according to SAM. Systematic names shown in brackets.

  1. Supplementary Materials