Pharmacokinetic-Pharmacodynamic Model of Newly Developed Dexibuprofen Sustained Release Formulations

Table 1

Formulation prepared by wet granulation method (F₁–F₁₀) for dexibuprofen.

F^a	DXI	HPMC	Xanthen	Avicel PH 102	Magnesium stearate	Aerosil	PVP-k-29/32	Total (mg/tab)
F1	300	37.5	—	130	5	2.5	25	500
F2	300	75	—	92.5	5	2.5	25	500
F3	300	112.5	—	55	5	2.5	25	500
F4	300	150	—	17.5	5	2.5	25	500
F5	300	—	112.5	55	5	2.5	25	500
F6	300	—	37.5	130	5	2.5	25	500
F7	300	—	75	92.5	5	2.5	25	500
F8	300	—	150	17.5	5	2.5	25	500
F9	300	—	50	117.5	5	2.5	25	500
F10	300	—	12.5	160	5	2.5	25	500

aCode of formulations.