Pharmacokinetic-Pharmacodynamic Model of Newly Developed Dexibuprofen Sustained Release Formulations

Table 2

Mean pharmacokinetic profile (𝑛=6).

Drug name	𝐶max	𝑇max	AUC0–t	𝑡1/2	𝑘el	AUC0–∞
IR	13.812; (1.072)	2.25; (0.273)	45.591; (6.331)	2.188; (0.175)	0.318; (0.024)	47.621; (6.242)
SR	14.178; (0.701)	5.00; (1.095)	117.843; (14.537)	4.772; (0.303)	0.145; (0.008)	122.620; (14.552)

^aImmediate release (IR) tablets.
^bSustained release (SR) tablets.
cResults represent the mean of replicate determination with the standard deviation given in parenthesis.
^†Significantly higher than IR tablets.
^‡Significantly lower than IR tablets.