Pharmacokinetic-Pharmacodynamic Model of Newly Developed Dexibuprofen Sustained Release Formulations

Table 4

Pain response versus plasma concentration of dexibuprofen (reference product).

Time points (h)	Pain response						Plasma concentration (mcg/mL)
	V1^a	V2^a	V3^a	V4^a	V5^a	V6^a	V1^a	V2^a	V3^a	V4^a	V5^a	V6^a
0	0.7	0.6	1.7	1.6	2.1	1.3	0	0	0	0	0	0
2	4.3	2.9	4.3	3.7	4.6	3.7	5.9826	6.3614	4.6985	7.4978	7.3956	5.3869
4	8.9	7.5	6.9	7.4	8.5	6.4	12.4958	11.3057	12.0498	10.2584	12.0394	13.0695
6	9.2	8.5	8.7	9	9.3	8.9	8.9375	9.5473	8.9573	8.5893	9.2738	9.4752

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