Synergistic Effect between Maternal Infection and Adolescent Cannabinoid Exposure on Serotonin 5HT_1A Receptor Binding in the Hippocampus: Testing the “Two Hit” Hypothesis for the Development of Schizophrenia

Table 1

Effect of prenatal poly I:C exposure and adolescent HU210 treatment on plasma TNF-α levels in offspring euthanized on postnatal day 55 and 65 (𝑛= 6-7 per treatment group).

	VEH-VEH		VEH-HU210		POLY I:C-VEH		POLY I:C-HU210
	PND 55	PND 65	PND 55	PND 65	PND 55	PND 65	PND 55	PND 65
TNF-α (ng/mL)	41.3±0.5	60.2±8.8	40.7±0.4	51.5±1.8	43.7±1.0^*#	58.1±8.7	41.8±0.5^&	49.4±0.8

Data are presented as average ± SEM, *𝑃=0.02 compared to VEH-VEH group; ^#𝑃=0.001 and ^&𝑃=0.047 compared to VEH-HU210 group in LSD post hoc tests.