Table of Contents
ISRN Obesity
Volume 2012 (2012), Article ID 490870, 6 pages
http://dx.doi.org/10.5402/2012/490870
Research Article

Aqueous Extract from Pepino (Solanum muricatum Ait.) Attenuated Hyperlipidemia and Cardiac Oxidative Stress in Diabetic Mice

1School of Nutrition, Chung Shan Medical University, Taichung 404, Taiwan
2Department of Nutrition, Chung Shan Medical University Hospital, Taichung 404, Taiwan
3Department of Nutrition, China Medical University, Taichung 404, Taiwan

Received 18 March 2012; Accepted 30 April 2012

Academic Editors: D. Fernandez-Twinn, B. Navia, and D. Ofir

Copyright © 2012 Zhi-hong Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study examined the lipid-lowering and cardiac protective effects of aqueous extract of pepino (Solanum muricatum Ait.) in type 2 diabetic mice. Pepino at 1, 2, or 5% was supplied for 8 weeks. Results showed that pepino significantly decreased water intake and epididymal fat pad weight in diabetic mice ( 𝑃 < 0 . 0 5 ). Pepino treatments also significantly reduced plasma glucose and insulin levels, HOMA-IR index, and improved oral glucose tolerance ( 𝑃 < 0 . 0 5 ). Plasma and hepatic levels of triglyceride and total cholesterol (TC) were higher in diabetic groups when compared with normal group ( 𝑃 < 0 . 0 5 ), pepino treatments at 2 and 5% decreased triglyceride and TC levels in both plasma and liver ( 𝑃 < 0 . 0 5 ). Diabetes enhanced mRNA expression of resistin and diacylglycerol acyltransferase1 (DGAT1) in epididymal fat pad ( 𝑃 < 0 . 0 5 ); however, pepino intake significantly suppressed mRNA expression of resistin and DGAT1 in epididymal fat pad ( 𝑃 < 0 . 0 5 ). Pepino intake significantly reduced reactive oxygen species level, increased glutathione level, and retained glutathione peroxidase and catalase activities in cardiac tissues ( 𝑃 < 0 . 0 5 ). These findings suggest that pepino could be considered as a functional food for the alleviation of type 2 diabetes.