Research Article

Looking into Task-Specific Activation Using a Prosthesis Substituting Vision with Audition

Table 1

Overview of brain activation foci during the sensory substitution conditions.

Brain areaCluster size 𝑍 score 𝑥 , 𝑦 , 𝑧 { mm}

Control > rest
Left postcentral gyrus (BA 1–3)14665.50−44; −28; 66
Left precentral gyrus (BA 4–6)( )4.73−50; −20; 62
Right lentiform nucleus, putamen1924.7824; 2; 6
Right insula( )4.9140; −8; 0
Left superior temporal gyrus (BA 22)1204.30−44; −18; −4
Left lentiform nucleus, putamen1374.24−22; 0; 4
Left claustrum/insula( )3.66−34; 0; 0
Right paracentral lobule/precuneus (BA 5–7)143.8220; −42; 50
Left superior frontal gyrus (BA 9)1533.78−20; 46; 32
Right middle frontal gyrus (BA 9)383.6464; 12; 34
Left thalamus173.47−18; −26; 8
Right superior frontal gyrus (BA 9)753.2026; 58; 28
Right transverse temporal gyrus (BA 41)113.1634; −26; 12
Left precuneus (BA 7)103.15−6; −60; 62

Localization > control
Right superior frontal gyrus (BA 8)14595.284; 30; 48
Right superior frontal gyrus (BA 6)( )4.982; 22; 54
Left cerebellum6494.85−2; −34; −2
Right inferior frontal gyrus (BA 47)4464.8042; 18; −6
Left insula (BA 13)4814.80−34; 22; 0
Left inferior parietal lobule (BA 40)12454.76−42; −52; 50
Left superior parietal lobule (BA 7)( )4.53−32; −64; 46
Left precuneus (BA 7)( )4.37−28; −50; 50
Left middle frontal gyrus (BA 6)584.71−28; 6; 56
Right middle frontal gyrus (BA 9)10114.7154; 28; 30
Left inferior frontal gyrus (BA 46)5594.47−48; 44; 2
Right cerebellum2404.478; −46; −14
Left cingulate gyrus (BA 23)1464.32−4; −18; 32
Left caudate body333.84−18; −6; 24
Right middle frontal gyrus (BA 6)1233.7428; 14; 54
Right caudate body293.6110; 2; 10
Right superior parietal lobule (BA 7)1373.5934; −64; 50
Right precuneus (BA 7)( )3.2918; −68; 50
Right precuneus (BA 7)183.198; −72; 52
Right inferior parietal lobule (BA 40)103.1540; −44; 44

Orientation > control
Right inferior frontal gyrus (BA 47)1224.8138; 20; −4
Left thalamus1374.76−16; −10; 8
Left inferior parietal lobule (BA 40)5984.75−40; −50; 46
Left superior parietal lobule (BA 7)( )4.39−32; −48; 48
Left superior parietal lobule/precuneus (BA 7)( )4.08−30; −66; 44
Left middle frontal gyrus (BA 9)4864.72−42; 22; 36
Left inferior frontal gyrus (BA 45)1894.68−32; 26; 6
Right superior frontal gyrus (BA 8)7934.522; 34; 50
Left substantia nigra984.38−12; −16; −8
Right cerebellum314.146; −48; −20
Right middle frontal gyrus (BA 9)453.9244; 2; 40
Right middle frontal gyrus (BA 9)723.8858; 28; 32
Left middle frontal gyrus (BA 9-10)833.80−42; 48; 20
Left inferior frontal gyrus (BA 46)503.61−46; 42; 4
Left cingulate gyrus (BA 23)103.76−8; −24; 32

Overview of brain activation peaks in the contrasts {SSD control condition minus rest}, {SSD localization minus SSD control, masked (inclusive) with SSD Localization minus rest}, and {SSD orientation minus SSD control, masked (inclusive) with SSD Orientation minus rest} from random-effect analysis (at 𝑃 < 0 . 0 5 , FDR corrected). Coordinates are reported in MNI space, as given by SPM2, and correspond only approximately to Talairach and Tournoux space [21]. BA: Brodmann area. ( ) belonging to the same voxels cluster.