Table of Contents
ISRN Cardiology
Volume 2012, Article ID 501894, 7 pages
http://dx.doi.org/10.5402/2012/501894
Research Article

MMP-2 and sTNF-R1 Variability in Patients with Essential Hypertension: 1-Year Follow-Up Study

1Cardiocirculatory Unit, Research Center, Hospital Universitario y Politécnico La Fe, 46009 Valencia, Spain
2Internal Medicine, Hospital Universitario y Politécnico La Fe, 46009 Valencia, Spain
3Cardiology Unit, Hospital Clínico Universitario de Santiago de Compostela, 15706 Santiago de Compostela, Spain
4Cardiology Unit, Hospital Universitario y Politécnico La Fe, 46009 Valencia, Spain
5Cardiology Unit, Hospital San Francesc de Borja, 46702 Gandía, Spain
6Cell Biology and Pathology Unit, Research Center, Hospital Universitario y Politécnico La Fe, 46009 Valencia, Spain

Received 27 July 2012; Accepted 15 August 2012

Academic Editors: F. Quaini and F. Russell

Copyright © 2012 Núria Carpena et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study is to analyze MMP-2 and sTNF-R1 variability, potent predictors of cardiovascular events, in stable hypertensive patients during a 12-month followup. 234 asymptomatic patients (age 6 0 Β± 1 3 , 136 male) out of 252 patients with essential hypertension were followed up. MMP-2 and sTNF-R1 were measured at baseline and after 12 months (stage I). To compare MMP-2 and sTNF-R1 levels over time interval, we used the statistical method of Bland-Altman. MMP-2 and sTNF-R1 reproducibility was good in our patients for the two intervals with a coefficient of reproducibility of 8.2% and 11.3%, respectively. The percentages of patients within 1.96 × standard deviation of the mean were 93.6% and 92.7%. An elevated coefficient of correlation was obtained for MMP-2, basal versus stage I ( π‘Ÿ = 0 . 5 5 , 𝑃 < 0 . 0 0 0 1 ) and for sTNF-R1 ( π‘Ÿ = 0 . 7 5 , 𝑃 < 0 . 0 0 0 1 ). There is good stability in MMP-2 and sTNF-R1 levels in a followup study of patients with stable hypertension. As a consequence, assessment of its concentrations may be a useful tool for monitoring the follow-up of these patients. Measured variations in MMP-2 and sTNF-R1 levels, exceeding 8.2% and 11.3%, respectively, may indicate an increase in cardiovascular risk, thus, could be used to optimizing treatment than blood pressure control alone.