Table of Contents
ISRN Otolaryngology
Volume 2012, Article ID 502746, 6 pages
http://dx.doi.org/10.5402/2012/502746
Clinical Study

Developmental Disabilities and Intracranial Abnormalities in Children with Symptomatic Cytomegalovirus and Cochlear Implants

1Division of Pediatric Otolaryngology Head and Neck Surgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
2Division of Developmental and Behavioral Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
3Division of Audiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
4Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
5Division of Biostatistics and Epidemiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA

Received 6 November 2012; Accepted 26 November 2012

Academic Editors: D. C. Alpini, Z. Makura, M. Sone, and C.-H. Wang

Copyright © 2012 Catherine K. Hart et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To examine the association of intracranial radiographic abnormalities and developmental measures with outcomes in children with congenital symptomatic cytomegalovirus (CMV) and cochlear implants (CI). Design/Methods. It was a retrospective review of 15 children implanted from 2004 to 2010. Preimplant nonverbal intelligence quotient/developmental quotient (IQ/DQ) and head circumference (HC) were obtained. Computed tomography and magnetic resonance imaging of the brain and post-CI audiometry and language assessments were reviewed. Results. Eleven children (73%) had cognitive delay. Most had >1 developmental disability. Median IQ/DQ was 65 (23–90). All had imaging abnormalities. Most imaging abnormalities were in parietal (60%) and temporal (60%) lobes. Children with HC < 5th percentile had poorer median post-CI PTA (38 dB versus 27 dB, ). Periventricular calcifications were associated with lower receptive ( , ) and expressive ( , ) language. Because IQ/DQ was associated with periventricular calcifications ( , ) and small HC ( , ), their relationships with language appear partially driven by IQ/DQ. Conclusions. The location of brain abnormalities appears to correlate with worse outcomes after CI. These findings may allow for more accurate counseling of parents regarding anticipated postimplantation performance.