Table of Contents
ISRN Pathology
Volume 2012, Article ID 519351, 8 pages
http://dx.doi.org/10.5402/2012/519351
Clinical Study

Assessment of Histopathological Response in Gastric and Gastro-Oesophageal Junction Adenocarcinoma following Neoadjuvant Chemotherapy: Which Scoring System to Use?

1Departments of Gastrointestinal Surgery and Histopathology, University Hospital of South Manchester, Manchester M23 9LT, UK
2Salford Royal NHS Foundation Trust, Manchester M6 8HD, UK
3Translational Radiobiology Group, School of Cancer and Enabling Sciences, The University of Manchester, Manchester Academic Health Science Centre, Christie Hospital NHS Trust, Manchester M20 4BX, UK

Received 26 June 2012; Accepted 19 July 2012

Academic Editors: A. Navarro, A. Stringer, and T. Yazawa

Copyright © 2012 A. Mirza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Ferlay, H. R. Shin, F. Bray, D. Forman, C. Mathers, and D. M. Parkin, “Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008,” International Journal of Cancer, vol. 127, no. 12, pp. 2893–2917, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. CRC. Cancer Research Uk, CancerStats—Key Facts, London, UK, 2009.
  3. K. Dolan, R. Sutton, S. J. Walker, A. Morris, F. Campbell, and E. M. Williams, “New classification of oesophageal and gastric carcinomas derived from changinq patterns in epidemiology,” British Journal of Cancer, vol. 80, no. 5-6, pp. 834–842, 1999. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Lagergren, R. Bergström, A. Lindgren, and O. Nyrén, “Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma,” The New England Journal of Medicine, vol. 340, no. 11, pp. 825–831, 1999. View at Publisher · View at Google Scholar · View at Scopus
  5. J. R. Siewert and H. J. Stein, “Classification of adenocarcinoma of the oesophagogastric junction,” British Journal of Surgery, vol. 85, no. 11, pp. 1457–1459, 1998. View at Publisher · View at Google Scholar · View at Scopus
  6. D. Cunningham, W. H. Allum, S. P. Stenning et al., “Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer,” The New England Journal of Medicine, vol. 355, no. 1, pp. 11–20, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. A. M. Mandard, F. Dalibard, J. C. Mandard et al., “Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Clinicopathologic correlations,” Cancer, vol. 73, no. 11, pp. 2680–2686, 1994. View at Google Scholar
  8. L. R. Chirieac, S. G. Swisher, J. A. Ajani et al., “Posttherapy pathologic stage predicts survival in patients with esophageal carcinoma receiving preoperative chemoradiation,” Cancer, vol. 103, no. 7, pp. 1347–1355, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Webb, D. Cunningham, J. H. Scarffe et al., “Randomized trial comparing epirubicin, cisplatin, and fluorouracil versus fluorouracil, doxorubicin, and methotrexate in advanced esophagogastric cancer,” Journal of Clinical Oncology, vol. 15, no. 1, pp. 261–267, 1997. View at Google Scholar · View at Scopus
  10. Y. Ninomiya, A. Yanagisawa, Y. Kato, T. Kitagawa, S. Ishihara, and T. Nakajima, “Histological indications of a favorable prognosis with far-advanced gastric carcinomas after preoperative chemotherapy,” Journal of Cancer Research and Clinical Oncology, vol. 125, no. 12, pp. 699–706, 1999. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Becker, J. D. Mueller, C. Schulmacher et al., “Histomorphology and grading of regression in gastric carcinoma treated with neoadjuvant chemotherapy,” Cancer, vol. 98, no. 7, pp. 1521–1530, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. A. M. Lowy, B. W. Feig, N. Janjan et al., “A pilot study of preoperative chemoradiotherapy for resectable gastric cancer,” Annals of Surgical Oncology, vol. 8, no. 6, pp. 519–524, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. J. A. Ajani, P. F. Mansfield, C. H. Crane et al., “Paclitaxel-based chemoradiotherapy in localized gastric carcinoma: degree of pathologic response and not clinical parameters dictated patient outcome,” Journal of Clinical Oncology, vol. 23, no. 6, pp. 1237–1244, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. K. R. Fareed, M. Ilyas, P. V. Kaye et al., “Tumour regression grade (TRG) analyses in patients with resectable gastro-oesophageal adenocarcinomas treated with platinum-based neoadjuvant chemotherapy,” Histopathology, vol. 55, no. 4, pp. 399–406, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. J. R. Landis and G. G. Koch, “An application of hierarchical Kappa type statistics in the assessment of majority agreement among multiple observers,” Biometrics, vol. 33, no. 2, pp. 363–374, 1977. View at Google Scholar · View at Scopus
  16. A. Rullier, C. Laurent, M. Capdepont, V. Vendrely, P. Bioulac-Sage, and E. Rullier, “Impact of tumor response on survival after radiochemotherapy in locally advanced rectal carcinoma,” American Journal of Surgical Pathology, vol. 34, no. 4, pp. 562–568, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. J. R. Siewert, K. Böttcher, H. J. Stein, and J. D. Roder, “Relevant prognostic factors in gastric cancer: ten-year results of the German Gastric Cancer Study,” Annals of Surgery, vol. 228, no. 4, pp. 449–461, 1998. View at Publisher · View at Google Scholar · View at Scopus
  18. A. G. Casson, S. J. Darnton, S. Subramanian, and L. Hiller, “What is the optimal distal resection margin for esophageal carcinoma?” Annals of Thoracic Surgery, vol. 69, no. 1, pp. 205–209, 2000. View at Publisher · View at Google Scholar · View at Scopus
  19. K. R. Fareed, P. Kaye, I. N. Soomro et al., “Biomarkers of response to therapy in oesophago-gastric cancer,” Gut, vol. 58, no. 1, pp. 127–143, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Luthra, T. T. Wu, M. G. Luthra et al., “Gene expression profiling of localized esophageal carcinomas: association with pathologic response to preoperative chemoradiation,” Journal of Clinical Oncology, vol. 24, no. 2, pp. 259–267, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Yamada, T. Arao, T. Gotoda et al., “Identification of prognostic biomarkers in gastric cancer using endoscopic biopsy samples,” Cancer Science, vol. 99, no. 11, pp. 2193–2199, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Nakano, C. Huang, D. Liu et al., “Evaluations of biomarkers associated with 5-FU sensitivity for non-small-cell lung cancer patients postoperatively treated with UFT,” British Journal of Cancer, vol. 95, no. 5, pp. 607–615, 2006. View at Publisher · View at Google Scholar · View at Scopus