Bioequivalence Study of Donepezil Hydrochloride Tablets in Healthy Male Volunteers

Table 1

Comparison of donepezil pharmacokinetic parameters after single oral dose of 5 mg reference product (Aricept) and test product (Tonizep).

Pharmacokinetic; parameter	Reference product; (Aricept)	Test product; (Tonizep)
𝐶^1max (ng/mL)	18.93 ± 3.82	20.42 ± 4.50
𝑇^2max (hr)	2.0 (1.0–3.0)	2.0 (1.0–3.0)
AUC^10−∞ (ng·hr/mL)	1277.47 ± 328.51	1375.01 ± 369.01
𝑡^11/2 (hr)	90.7 ± 18.1	91.5 ± 21.3

¹Represented as mean ± SD. ²Represented as median (range).