Table of Contents
ISRN Pharmaceutics
Volume 2012, Article ID 528079, 9 pages
http://dx.doi.org/10.5402/2012/528079
Review Article

Osmotic Drug Delivery System as a Part of Modified Release Dosage Form

1Department of Pharmaceutics, Kalol Institute of Pharmacy, Gujarat, Kalol 382721, India
2Department of Pharmaceutics, R. K. College of Pharmacy, Gujarat, Rajkot 360020, India
3Department of Pharmaceutics, DDIT Pharmacy College, Nadiad 387001, India

Received 9 March 2012; Accepted 8 May 2012

Academic Editors: H. Arima, M. Efentakis, and G. Frenning

Copyright © 2012 Rajesh A. Keraliya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Conventional drug delivery systems are known to provide an immediate release of drug, in which one can not control the release of the drug and can not maintain effective concentration at the target site for longer time. Controlled drug delivery systems offer spatial control over the drug release. Osmotic pumps are most promising systems for controlled drug delivery. These systems are used for both oral administration and implantation. Osmotic pumps consist of an inner core containing drug and osmogens, coated with a semipermeable membrane. As the core absorbs water, it expands in volume, which pushes the drug solution out through the delivery ports. Osmotic pumps release drug at a rate that is independent of the pH and hydrodynamics of the dissolution medium. The historical development of osmotic systems includes development of the Rose-Nelson pump, the Higuchi-Leeper pumps, the Alzet and Osmet systems, the elementary osmotic pump, and the push-pull system. Recent advances include development of the controlled porosity osmotic pump, and systems based on asymmetric membranes. This paper highlights the principle of osmosis, materials used for fabrication of pumps, types of pumps, advantages, disadvantages, and marketed products of this system.